Anticoagulants (factor Xa inhibitors)
- Direct Xa blockade → less thrombin generation
- Apixaban/rivaroxaban/edoxaban are oral
- Fondaparinux is parenteral/indirect
- AF stroke prevention + VTE are major uses
- Renal function + CYP3A/P-gp DDIs matter
- Andexanet reverses selected oral Xa inhibitors
- PCC is used when specific reversal is unavailable
Class at a glance
- Direct Xa blockade → less thrombin generation
Pharmacology
- Andexanet reverses selected oral Xa inhibitors
Clinical role
- Apixaban/rivaroxaban/edoxaban are oral
- Fondaparinux is parenteral/indirect
- AF stroke prevention + VTE are major uses
- PCC is used when specific reversal is unavailable
Pharmacologic distinctions
- Renal function + CYP3A/P-gp DDIs matter
Drugs in this class (3)
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