Anticoagulants (factor Xa inhibitors)
- Direct Xa blockade → less thrombin generation
- Apixaban/rivaroxaban/edoxaban are oral
- Fondaparinux is parenteral/indirect
- AF stroke prevention + VTE are major uses
- Renal function + CYP3A/P-gp DDIs matter
- Andexanet reverses selected oral Xa inhibitors
- PCC is used when specific reversal is unavailable
Class at a glance
- Direct Xa blockade → less thrombin generation
Pharmacology
- Andexanet reverses selected oral Xa inhibitors
Clinical role
- Apixaban/rivaroxaban/edoxaban are oral
- Fondaparinux is parenteral/indirect
- AF stroke prevention + VTE are major uses
- PCC is used when specific reversal is unavailable
Pharmacologic distinctions
- Renal function + CYP3A/P-gp DDIs matter
Self-check
- Which agent reverses selected oral Xa inhibitors?
Andexanet. - Which Xa-directed anticoagulant is parenteral and indirect?
Fondaparinux.
Drugs in this class (3)
Anticoagulants (factor Xa inhibitors) prescription history
Animated chart of estimated U.S. prescriptions per year, Antithrombotics (1914–2026). Direct anticoagulants highlighted from 2011.
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