Antibacterials (sulfonamides)
- PABA analogs → inhibit folate synthesis
- Sulfamethoxazole is usually paired with TMP
- Dapsone is chemically related but distinct
- Rash/SJS, cytopenia + crystalluria possible
- TMP-SMX can raise K+ and creatinine
- G6PD deficiency can increase hemolysis risk
Class at a glance
- PABA analogs → inhibit folate synthesis
Practical pearls
- Sulfamethoxazole is usually paired with TMP
Other practical pearls
- Dapsone is chemically related but distinct
- TMP-SMX can raise K+ and creatinine
Safety / monitoring
- Rash/SJS, cytopenia + crystalluria possible
- G6PD deficiency can increase hemolysis risk
Self-check
- How does Antibacterials (sulfonamides) work?
PABA analogs → inhibit folate synthesis. - Key risk with Antibacterials (sulfonamides)?
Rash/SJS, cytopenia + crystalluria possible.
Drugs in this class (3)
All drug classes · Open Antibacterials (sulfonamides) in the interactive console ↗