Antiarrhythmics (Vaughan-Williams IB)
- Weak/rapid Na+ channel blockade
- Preferential effect in ventricular tissue
- Lidocaine IV; mexiletine oral
- Little QT prolongation
- Main niche: ventricular arrhythmias
- CNS toxicity rises with high exposure
Class at a glance
- Weak/rapid Na+ channel blockade
Members / distinctions
- Main niche: ventricular arrhythmias
Safety / monitoring
- Preferential effect in ventricular tissue
- Lidocaine IV; mexiletine oral
- Little QT prolongation
Safety distinctions
- CNS toxicity rises with high exposure
Self-check
- How does Antiarrhythmics (Vaughan-Williams IB) work?
Weak/rapid Na+ channel blockade. - What is the main niche of class IB antiarrhythmics?
Ventricular arrhythmias.
Drugs in this class (3)
Antiarrhythmics (Vaughan-Williams IB) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026). Class IB highlighted from 1985.
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