Antiarrhythmics (Vaughan-Williams IB)
- Weak/rapid Na+ channel blockade
- Preferential effect in ventricular tissue
- Lidocaine IV; mexiletine oral
- Little QT prolongation
- Main niche: ventricular arrhythmias
- CNS toxicity rises with high exposure
Class at a glance
- Weak/rapid Na+ channel blockade
Members / distinctions
- Main niche: ventricular arrhythmias
Safety / monitoring
- Preferential effect in ventricular tissue
- Lidocaine IV; mexiletine oral
- Little QT prolongation
Safety distinctions
- CNS toxicity rises with high exposure
Self-check
- What is the main pharmacologic action of Antiarrhythmics (Vaughan-Williams IB)?
Weak/rapid Na+ channel blockade.
Drugs in this class (3)
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