Angiotensin receptor blockers (ARBs)
- AT1 blockers without bradykinin buildup
- HTN, HFrEF, albuminuric CKD
- Similar renal/K risks to ACE inhibitors
- Much less cough; less angioedema
- Losartan has a uricosuric effect
- Avoid in pregnancy
- Do not routinely combine with ACE inhibitor
Class at a glance
- AT1 blockers without bradykinin buildup
Practical pearls
- Much less cough; less angioedema
Clinical role
- HTN, HFrEF, albuminuric CKD
- Losartan has a uricosuric effect
- Do not routinely combine with ACE inhibitor
Safety / monitoring
- Similar renal/K risks to ACE inhibitors
- Avoid in pregnancy
Self-check
- When should Angiotensin receptor blockers (ARBs) generally be avoided?
pregnancy.
- Should Angiotensin receptor blockers (ARBs) routinely be combined with ACE inhibitor?
No.
Drugs in this class (10)
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