Wilson disease
- Remove copper and prevent reaccumulation
- Chelators: penicillamine or trientine
- Zinc reduces intestinal copper absorption
- Treatment is lifelong
- Monitor liver, neurologic status + copper indices
- Acute liver failure may require transplant
Use at a glance
- Remove copper and prevent reaccumulation
Escalation / refractory disease
- Acute liver failure may require transplant
Treatment options
- Chelators: penicillamine or trientine
- Zinc reduces intestinal copper absorption
- Treatment is lifelong
Monitoring / follow-up
- Monitor liver, neurologic status + copper indices
Self-check
- What is monitored in Wilson disease?
Liver, neurologic status + copper indices. - What may acute liver failure in Wilson disease require?
Transplant.
Drugs used for this (2)
All clinical uses · Open Wilson disease in the interactive console ↗