Wilson disease
- Remove copper and prevent reaccumulation
- Chelators: penicillamine or trientine
- Zinc reduces intestinal copper absorption
- Treatment is lifelong
- Monitor liver, neurologic status + copper indices
- Acute liver failure may require transplant
Use at a glance
- Remove copper and prevent reaccumulation
Escalation / refractory disease
- Acute liver failure may require transplant
Treatment options
- Chelators: penicillamine or trientine
- Zinc reduces intestinal copper absorption
- Treatment is lifelong
Monitoring / follow-up
- Monitor liver, neurologic status + copper indices
Self-check
- What should be monitored during treatment of Wilson disease?
liver, neurologic status + copper indices.
- What is required for Acute liver failure in Wilson disease?
transplant.
Drugs used for this (2)
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