Ulcerative colitis (UC)
- Mild distal disease → mesalamine first
- More extensive mild disease → oral + rectal 5-ASA
- Steroid only for induction of active flares
- Moderate–severe → advanced biologic/small molecule
- Maintain steroid-free remission
- Acute severe UC → IV steroid, then rescue therapy
- Colectomy is curative for colitis
Use at a glance
- Mild distal disease → mesalamine first
Treatment options
- Steroid only for induction of active flares
- Maintain steroid-free remission
Other treatment options
- Acute severe UC → IV steroid, then rescue therapy
- Colectomy is curative for colitis
Practical pearls
- More extensive mild disease → oral + rectal 5-ASA
- Moderate–severe → advanced biologic/small molecule
Self-check
- What is used for moderate–severe UC?
An advanced biologic/small molecule. - Should steroids maintain UC remission?
No—induction only.
Drugs used for this (12)
All clinical uses · Open Ulcerative colitis (UC) in the interactive console ↗