Treatment-resistant schizophrenia (TRS)
- Confirm 2 adequate antipsychotic trials + adherence
- Clozapine is the treatment of choice
- Start clozapine promptly once TRS is established
- Use therapeutic levels/adherence before declaring failure
- ECT augmentation can help severe clozapine-resistant illness
- Antipsychotic polypharmacy is not a substitute for clozapine
Use at a glance
- Confirm 2 adequate antipsychotic trials + adherence
Practical pearls
- Use therapeutic levels/adherence before declaring failure
Treatment options
- Clozapine is the treatment of choice
- Antipsychotic polypharmacy is not a substitute for clozapine
Other practical pearls
- ECT augmentation can help severe clozapine-resistant illness
Clinical pearls
- Start clozapine promptly once TRS is established
Self-check
- What starts promptly once TRS is established?
Clozapine. - What should be confirmed before labeling schizophrenia treatment-resistant?
2 adequate antipsychotic trials + adherence.
Drugs used for this (1)
All clinical uses · Open Treatment-resistant schizophrenia (TRS) in the interactive console ↗