Treatment-resistant schizophrenia (TRS)
- Confirm 2 adequate antipsychotic trials + adherence
- Clozapine is the treatment of choice
- Start clozapine promptly once TRS is established
- Use therapeutic levels/adherence before declaring failure
- ECT augmentation can help severe clozapine-resistant illness
- Antipsychotic polypharmacy is not a substitute for clozapine
Use at a glance
- Confirm 2 adequate antipsychotic trials + adherence
Practical pearls
- Use therapeutic levels/adherence before declaring failure
Treatment options
- Clozapine is the treatment of choice
- Antipsychotic polypharmacy is not a substitute for clozapine
Other practical pearls
- ECT augmentation can help severe clozapine-resistant illness
Clinical pearls
- Start clozapine promptly once TRS is established
Self-check
- What should be started in Treatment-resistant schizophrenia (TRS)?
clozapine promptly once TRS is established.
- What treatment approach is used in Treatment-resistant schizophrenia (TRS)?
therapeutic levels/adherence before declaring failure.
Drugs used for this (1)
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