Sialorrhea (clozapine-induced)
- Reduce nighttime burden if dose timing permits
- Sublingual atropine/ipratropium are common local options
- Glycopyrrolate works but adds antimuscarinic GI burden
- Avoid worsening clozapine constipation
- Severe cases may use botulinum toxin
- Aspiration risk matters, especially during sleep
Use at a glance
- Reduce nighttime burden if dose timing permits
Practical pearls
- Sublingual atropine/ipratropium are common local options
- Glycopyrrolate works but adds antimuscarinic GI burden
Safety / pitfalls
- Avoid worsening clozapine constipation
Escalation / refractory disease
- Severe cases may use botulinum toxin
- Aspiration risk matters, especially during sleep
Self-check
- Which clozapine complication must sialorrhea treatment avoid worsening?
Constipation. - Why does severe clozapine sialorrhea matter during sleep?
Aspiration risk.
Drugs used for this (2)
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