Postpartum depression (PPD)
- Psychotherapy ± antidepressant for most cases
- SSRIs remain common, especially with prior response
- Zuranolone provides a rapid short oral course
- Brexanolone is rapid IV neuroactive-steroid therapy
- Severe suicidality/psychosis → urgent specialty care/ECT
- Breastfeeding + sedation considerations guide choice
Use at a glance
- Psychotherapy ± antidepressant for most cases
Choosing treatment
- Zuranolone provides a rapid short oral course
- Brexanolone is rapid IV neuroactive-steroid therapy
- Breastfeeding + sedation considerations guide choice
Practical pearls
- SSRIs remain common, especially with prior response
Other practical pearls
- Severe suicidality/psychosis → urgent specialty care/ECT
Self-check
- What is needed for postpartum depression with severe suicidality or psychosis?
Urgent specialty care/ECT. - Which PPD drug provides a rapid short oral course?
Zuranolone.
Drugs used for this (17)
All clinical uses · Open Postpartum depression (PPD) in the interactive console ↗