Pneumocystis jirovecii pneumonia (PJP) — prophylaxis

TMP-SMX is preferred prophylaxis
Use when immune status crosses disease-specific threshold
Alternatives: atovaquone, dapsone or aerosol pentamidine
Check G6PD before dapsone
Stop prophylaxis when immune recovery criteria are met
Regimen differs somewhat by HIV/transplant/oncology context

Use at a glance

TMP-SMX is preferred prophylaxis

Escalation / refractory disease

Alternatives: atovaquone, dapsone or aerosol pentamidine
Regimen differs somewhat by HIV/transplant/oncology context

Choosing treatment

Use when immune status crosses disease-specific threshold
Stop prophylaxis when immune recovery criteria are met

Practical pearls

Check G6PD before dapsone

Self-check

What should be stopped immediately in Pneumocystis jirovecii pneumonia (PJP) — prophylaxis?
prophylaxis when immune recovery criteria are met.
What should be checked in Pneumocystis jirovecii pneumonia (PJP) — prophylaxis?
G6PD before dapsone.

Drugs used for this (4)

Atovaquone ballicule — decagon mechanism diagram — Atovaquone — off-label

Pentamidine ballicule — decagon mechanism diagram — Pentamidine — off-label

Sulfamethoxazole ballicule — decagon mechanism diagram — Sulfamethoxazole — off-label

Trimethoprim ballicule — decagon mechanism diagram — Trimethoprim — off-label

All clinical uses · Open the interactive console ↗