Pneumocystis jirovecii pneumonia (PJP) — prophylaxis
- TMP-SMX is preferred prophylaxis
- Use when immune status crosses disease-specific threshold
- Alternatives: atovaquone, dapsone or aerosol pentamidine
- Check G6PD before dapsone
- Stop prophylaxis when immune recovery criteria are met
- Regimen differs somewhat by HIV/transplant/oncology context
Use at a glance
- TMP-SMX is preferred prophylaxis
Escalation / refractory disease
- Alternatives: atovaquone, dapsone or aerosol pentamidine
- Regimen differs somewhat by HIV/transplant/oncology context
Choosing treatment
- Use when immune status crosses disease-specific threshold
- Stop prophylaxis when immune recovery criteria are met
Practical pearls
- Check G6PD before dapsone
Self-check
- When should PJP prophylaxis stop?
When immune recovery criteria are met. - What is checked before dapsone prophylaxis?
G6PD before dapsone.
Drugs used for this (4)
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