Parkinson disease psychosis
- Remove nonessential psychosis-provoking drugs first
- Reduce PD drugs cautiously if motor function allows
- Pimavanserin is FDA-approved
- Clozapine is effective but needs ANC monitoring
- Quetiapine is common despite weaker evidence
- Avoid potent D2 blockers that worsen parkinsonism
- Check delirium/infection before labeling PD psychosis
Use at a glance
- Remove nonessential psychosis-provoking drugs first
Practical pearls
- Pimavanserin is FDA-approved
- Quetiapine is common despite weaker evidence
Choosing treatment
- Reduce PD drugs cautiously if motor function allows
Monitoring / follow-up
- Clozapine is effective but needs ANC monitoring
- Avoid potent D2 blockers that worsen parkinsonism
- Check delirium/infection before labeling PD psychosis
Self-check
- What is checked before labeling PD psychosis?
Delirium/infection before labeling PD psychosis. - Which blockers worsen parkinsonism and are avoided in PD psychosis?
Potent D2 blockers.
Drugs used for this (3)
All clinical uses · Open Parkinson disease psychosis in the interactive console ↗