Parkinson disease dementia (PDD)
- Optimize cognition while preserving motor function
- Rivastigmine is FDA-approved for PDD
- Donepezil is sometimes used off-label
- Treat delirium, sleep + anticholinergic burden
- Avoid dopamine-blocking antipsychotics if possible
- Caregiver/safety planning is essential
- Cholinesterase AEs: GI + bradycardia
Use at a glance
- Optimize cognition while preserving motor function
Practical pearls
- Rivastigmine is FDA-approved for PDD
- Donepezil is sometimes used off-label
Other practical pearls
- Treat delirium, sleep + anticholinergic burden
- Cholinesterase AEs: GI + bradycardia
Safety / pitfalls
- Avoid dopamine-blocking antipsychotics if possible
- Caregiver/safety planning is essential
Self-check
- Which drug is FDA-approved for PDD?
Rivastigmine. - What must be preserved while optimizing PDD cognition?
Motor function.
Drugs used for this (4)
All clinical uses · Open Parkinson disease dementia (PDD) in the interactive console ↗