Parkinson disease dementia (PDD)
- Optimize cognition while preserving motor function
- Rivastigmine is FDA-approved for PDD
- Donepezil is sometimes used off-label
- Treat delirium, sleep + anticholinergic burden
- Avoid dopamine-blocking antipsychotics if possible
- Caregiver/safety planning is essential
- Cholinesterase AEs: GI + bradycardia
Use at a glance
- Optimize cognition while preserving motor function
Practical pearls
- Rivastigmine is FDA-approved for PDD
- Donepezil is sometimes used off-label
Other practical pearls
- Treat delirium, sleep + anticholinergic burden
- Cholinesterase AEs: GI + bradycardia
Safety / pitfalls
- Avoid dopamine-blocking antipsychotics if possible
- Caregiver/safety planning is essential
Self-check
- What should be treated in Parkinson disease dementia (PDD)?
delirium, sleep + anticholinergic burden.
- What should be optimized in Parkinson disease dementia (PDD)?
cognition while preserving motor function.
Drugs used for this (1)
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