Organ transplantation — immunosuppression
- Use combination therapy to prevent rejection
- Calcineurin inhibitor is a common maintenance backbone
- Add antimetabolite ± glucocorticoid
- Induction biologic depends on organ + rejection risk
- TDM and DDI management are crucial
- Balance rejection against infection/malignancy toxicity
Use at a glance
- Use combination therapy to prevent rejection
Practical pearls
- Calcineurin inhibitor is a common maintenance backbone
Other practical pearls
- Add antimetabolite ± glucocorticoid
Clinical pearls
- TDM and DDI management are crucial
Choosing treatment
- Induction biologic depends on organ + rejection risk
- Balance rejection against infection/malignancy toxicity
Self-check
- What drug strategy prevents transplant rejection?
Combination therapy. - What risk must transplant rejection prevention balance?
Infection/malignancy toxicity.
Drugs used for this (5)
All clinical uses · Open Organ transplantation — immunosuppression in the interactive console ↗