Obesity / chronic weight management
- Lifestyle + long-term medical management
- Pharmacotherapy if BMI/risk justifies it
- Tirzepatide/semaglutide: greatest current efficacy
- Orforglipron adds an oral GLP-1 option
- Match drug to diabetes, CV risk + AEs
- Weight regain is common after stopping therapy
- Severe obesity → consider metabolic surgery
Use at a glance
- Lifestyle + long-term medical management
Treatment options
- Severe obesity → consider metabolic surgery
Other treatment options
- Tirzepatide/semaglutide: greatest current efficacy
- Orforglipron adds an oral GLP-1 option
- Weight regain is common after stopping therapy
Choosing treatment
- Pharmacotherapy if BMI/risk justifies it
- Match drug to diabetes, CV risk + AEs
Self-check
- What should guide drug in Obesity / chronic weight management?
diabetes, CV risk + AEs.
- What is recommended for Severe obesity in Obesity / chronic weight management?
consider metabolic surgery.
Drugs used for this (7)
All clinical uses · Open the interactive console ↗
