Nephrogenic diabetes insipidus
- Remove reversible cause when possible
- Maintain free-water access
- Thiazide + low-solute diet reduces urine volume
- Amiloride is especially useful for lithium-induced disease
- NSAID can reduce urine output but adds renal risk
- Desmopressin is usually much less effective than in central DI
Use at a glance
- Remove reversible cause when possible
Practical pearls
- Maintain free-water access
- Thiazide + low-solute diet reduces urine volume
Other practical pearls
- Amiloride is especially useful for lithium-induced disease
- Desmopressin is usually much less effective than in central DI
Clinical pearls
- NSAID can reduce urine output but adds renal risk
Self-check
- Which drug is especially useful in lithium-induced nephrogenic DI?
Amiloride. - How does desmopressin efficacy compare with central DI?
Usually much lower.
Drugs used for this (2)
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