Lennox-Gastaut syndrome (LGS)
- Use broad-spectrum combination therapy
- Valproate is a common foundation
- Clobazam, rufinamide, lamotrigine + cannabidiol are options
- Fenfluramine is another approved option
- Ketogenic diet/VNS/callosal surgery may help
- Complete seizure freedom is uncommon
Use at a glance
- Use broad-spectrum combination therapy
Treatment options
- Valproate is a common foundation
- Ketogenic diet/VNS/callosal surgery may help
Practical pearls
- Clobazam, rufinamide, lamotrigine + cannabidiol are options
Other practical pearls
- Fenfluramine is another approved option
- Complete seizure freedom is uncommon
Self-check
- What drug strategy is used in LGS?
Broad-spectrum combination therapy. - Is complete seizure freedom common in LGS?
No.
Drugs used for this (4)
All clinical uses · Open Lennox-Gastaut syndrome (LGS) in the interactive console ↗