Lennox-Gastaut syndrome (LGS)
- Use broad-spectrum combination therapy
- Valproate is a common foundation
- Clobazam, rufinamide, lamotrigine + cannabidiol are options
- Fenfluramine is another approved option
- Ketogenic diet/VNS/callosal surgery may help
- Complete seizure freedom is uncommon
Use at a glance
- Use broad-spectrum combination therapy
Treatment options
- Valproate is a common foundation
- Ketogenic diet/VNS/callosal surgery may help
Practical pearls
- Clobazam, rufinamide, lamotrigine + cannabidiol are options
Other practical pearls
- Fenfluramine is another approved option
- Complete seizure freedom is uncommon
Self-check
- What treatment approach is used in Lennox-Gastaut syndrome (LGS)?
broad-spectrum combination therapy.
Drugs used for this (4)
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