Lambert-Eaton myasthenic syndrome (LEMS)
- Treat underlying cancer when present
- Amifampridine improves neuromuscular transmission
- Pyridostigmine can provide additional symptomatic benefit
- Immunotherapy for persistent autoimmune disease
- Screen for small-cell lung cancer
- Avoid drugs that worsen neuromuscular transmission
Use at a glance
- Treat underlying cancer when present
Practical pearls
- Amifampridine improves neuromuscular transmission
- Pyridostigmine can provide additional symptomatic benefit
Treatment options
- Immunotherapy for persistent autoimmune disease
- Screen for small-cell lung cancer
Safety / pitfalls
- Avoid drugs that worsen neuromuscular transmission
Self-check
- Which LEMS contributor should be treated when present?
Underlying cancer. - Which cancer should be screened for in LEMS?
Small-cell lung cancer.
Drugs used for this (1)
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