Cushing syndrome
- Identify source of cortisol excess
- Resect causal tumor when possible
- Medical cortisol blockade if surgery fails/is delayed
- Osilodrostat/metyrapone/ketoconazole are key options
- Treat diabetes, HTN, infection + thrombosis risk
- Prevent adrenal insufficiency from overtreatment
Use at a glance
- Identify source of cortisol excess
Choosing treatment
- Medical cortisol blockade if surgery fails/is delayed
Practical pearls
- Osilodrostat/metyrapone/ketoconazole are key options
Treatment selection
- Resect causal tumor when possible
- Prevent adrenal insufficiency from overtreatment
Other practical pearls
- Treat diabetes, HTN, infection + thrombosis risk
Self-check
- What can cortisol overtreatment cause?
Adrenal insufficiency. - When is medical cortisol blockade used?
If surgery fails or is delayed.
Drugs used for this (1)
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