Cushing syndrome — hypercortisolism
- Remove cortisol-producing tumor if possible
- Surgery is preferred curative treatment
- Medical therapy if persistent/inoperable disease
- osilodrostat/metyrapone/ketoconazole
- Pituitary drugs or mifepristone in selected cases
- Treat infection, diabetes, HTN + thrombosis risk
- Avoid abrupt cortisol overcorrection
Use at a glance
- Remove cortisol-producing tumor if possible
Treatment options
- Surgery is preferred curative treatment
Choosing treatment
- Medical therapy if persistent/inoperable disease
- osilodrostat/metyrapone/ketoconazole
- Pituitary drugs or mifepristone in selected cases
Safety / pitfalls
- Treat infection, diabetes, HTN + thrombosis risk
- Avoid abrupt cortisol overcorrection
Self-check
- What should be treated in Cushing syndrome — hypercortisolism?
infection, diabetes, HTN + thrombosis risk.
- What should generally be avoided in Cushing syndrome — hypercortisolism?
abrupt cortisol overcorrection.
Drugs used for this (3)
All clinical uses · Open the interactive console ↗
