Cryptococcosis
- CNS/severe disease needs induction combination therapy
- amphotericin B + flucytosine
- Then prolonged fluconazole consolidation/maintenance
- Measure/opening pressure in cryptococcal meningitis
- Repeated lumbar puncture may be lifesaving
- HIV timing of ART requires specialist coordination
Use at a glance
- CNS/severe disease needs induction combination therapy
- amphotericin B + flucytosine
Practical pearls
- Then prolonged fluconazole consolidation/maintenance
Other practical pearls
- Measure/opening pressure in cryptococcal meningitis
Clinical pearls
- Repeated lumbar puncture may be lifesaving
- HIV timing of ART requires specialist coordination
Self-check
- Which induction combination treats CNS/severe cryptococcosis?
Amphotericin B + flucytosine. - What requires specialist coordination in HIV-associated cryptococcosis?
ART timing.
Drugs used for this (2)
All clinical uses · Open Cryptococcosis in the interactive console ↗