Chronic lymphocytic leukemia (CLL)
- Observe asymptomatic early CLL until treatment criteria are met
- Targeted oral therapy has largely replaced routine chemoimmunotherapy
- BTK inhibitor or venetoclax-based regimen are major options
- TP53/del17p strongly affects choice
- Prevent/treat infection and hypogammaglobulinemia when needed
- Do not treat lymphocyte count alone
Use at a glance
- Observe asymptomatic early CLL until treatment criteria are met
Treatment options
- Targeted oral therapy has largely replaced routine chemoimmunotherapy
- BTK inhibitor or venetoclax-based regimen are major options
- TP53/del17p strongly affects choice
Choosing treatment
- Prevent/treat infection and hypogammaglobulinemia when needed
Safety / pitfalls
- Do not treat lymphocyte count alone
Self-check
- How should asymptomatic early CLL be managed before treatment criteria are met?
Observe. - Should CLL be treated based on lymphocyte count alone?
No.
Drugs used for this (4)
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