Chemotherapy-induced nausea/vomiting (CINV)
- Prophylaxis is based on emetogenic risk
- Highly emetogenic: multi-drug prevention
- 5-HT3 + NK1 + dexamethasone + olanzapine
- Give prophylaxis BEFORE chemotherapy
- Delayed nausea needs continued coverage
- Breakthrough → add different mechanism
- Prior-cycle failure predicts future risk
Use at a glance
- Prophylaxis is based on emetogenic risk
Treatment options
- Highly emetogenic: multi-drug prevention
- 5-HT3 + NK1 + dexamethasone + olanzapine
- Give prophylaxis BEFORE chemotherapy
- Breakthrough → add different mechanism
Practical pearls
- Delayed nausea needs continued coverage
Other practical pearls
- Prior-cycle failure predicts future risk
Self-check
- What determines CINV prophylaxis?
Emetogenic risk. - What does delayed CINV need?
Continued coverage.
Drugs used for this (8)
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