Bipolar disorder (depression)
- Avoid antidepressant monotherapy
- Quetiapine is a major first-line option
- Lurasidone/cariprazine/lumateperone useful
- Lithium/lamotrigine also evidence-based
- Choose by polarity, prior response + AEs
- Antidepressant only selectively + mood stabilizer
Use at a glance
- Avoid antidepressant monotherapy
Treatment options
- Quetiapine is a major first-line option
Practical pearls
- Lurasidone/cariprazine/lumateperone useful
- Lithium/lamotrigine also evidence-based
Other practical pearls
- Choose by polarity, prior response + AEs
- Antidepressant only selectively + mood stabilizer
Self-check
- Which antidepressant strategy is avoided in bipolar depression?
Antidepressant monotherapy. - What guides bipolar-depression drug choice?
Polarity, prior response + AEs.
Drugs used for this (7)
All clinical uses · Open Bipolar disorder (depression) in the interactive console ↗