Bipolar disorder (acute mania/mixed)
- Stop antidepressant/stimulant contributors
- Severe mania often needs combination therapy
- Lithium or valproate + antipsychotic common
- Antipsychotic monotherapy can also work
- Lithium favored for classic euphoric mania
- Valproate often useful in mixed presentations
- Avoid antidepressant monotherapy
Use at a glance
- Stop antidepressant/stimulant contributors
Treatment options
- Lithium or valproate + antipsychotic common
- Antipsychotic monotherapy can also work
- Lithium favored for classic euphoric mania
- Valproate often useful in mixed presentations
Other treatment options
- Severe mania often needs combination therapy
Safety / pitfalls
- Avoid antidepressant monotherapy
Self-check
- Which contributors should be stopped in acute mania/mixed episodes?
Antidepressants/stimulants. - What does severe mania often need?
Combination therapy.
Drugs used for this (11)
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