Antimuscarinic toxicity
- Support airway, temperature + agitation first
- Benzodiazepine for severe agitation/seizure
- Physostigmine can rapidly reverse central syndrome
- only in selected pure antimuscarinic toxicity
- Avoid physostigmine with QRS widening/TCA concern
- Cool, hydrate + treat urinary retention as needed
Use at a glance
- Support airway, temperature + agitation first
Practical pearls
- Cool, hydrate + treat urinary retention as needed
Treatment options
- Benzodiazepine for severe agitation/seizure
Safety / pitfalls
- Physostigmine can rapidly reverse central syndrome
- only in selected pure antimuscarinic toxicity
- Avoid physostigmine with QRS widening/TCA concern
Self-check
- Which antidote is avoided with QRS widening/TCA concern?
Physostigmine. - What comes first in antimuscarinic toxicity?
Support airway, temperature + agitation.
Drugs used for this (1)
All clinical uses · Open Antimuscarinic toxicity in the interactive console ↗