Acetaminophen toxicity
- N-acetylcysteine (NAC) is the antidote
- Start promptly if toxic exposure is possible
- Acute single ingestion → use Rumack-Matthew nomogram
- Treat when timing/level is unreliable but risk is high
- Follow AST/ALT, INR, creatinine + acetaminophen
- Massive toxicity may require dialysis + transplant care
Use at a glance
- N-acetylcysteine (NAC) is the antidote
Practical pearls
- Acute single ingestion → use Rumack-Matthew nomogram
Choosing treatment
- Start promptly if toxic exposure is possible
- Treat when timing/level is unreliable but risk is high
Monitoring / follow-up
- Follow AST/ALT, INR, creatinine + acetaminophen
- Massive toxicity may require dialysis + transplant care
Self-check
- Which antidote starts promptly for possible toxic acetaminophen exposure?
N-acetylcysteine (NAC). - Treat high-risk acetaminophen toxicity despite unreliable timing or level?
Yes.
Drugs used for this (1)
All clinical uses · Open Acetaminophen toxicity in the interactive console ↗