Acetaminophen toxicity
- N-acetylcysteine (NAC) is the antidote
- Start promptly if toxic exposure is possible
- Acute single ingestion → use Rumack-Matthew nomogram
- Treat when timing/level is unreliable but risk is high
- Follow AST/ALT, INR, creatinine + acetaminophen
- Massive toxicity may require dialysis + transplant care
Use at a glance
- N-acetylcysteine (NAC) is the antidote
Practical pearls
- Acute single ingestion → use Rumack-Matthew nomogram
Choosing treatment
- Start promptly if toxic exposure is possible
- Treat when timing/level is unreliable but risk is high
Monitoring / follow-up
- Follow AST/ALT, INR, creatinine + acetaminophen
- Massive toxicity may require dialysis + transplant care
Self-check
- What should be started in Acetaminophen toxicity?
promptly if toxic exposure is possible.
- What should be treated in Acetaminophen toxicity?
when timing/level is unreliable but risk is high.
Drugs used for this (1)
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