Precursor to metabolite: Clozapine oral suspension to Norclozapine

Clozapine oral suspension is converted to Norclozapine by CYP1A2.

The pair

Clozapine oral suspension — Clozapine oral suspension; same ANC monitoring as the tablets.
Norclozapine — Active clozapine metabolite; M1 agonist implicated in some clozapine effects.

Anything that inhibits or induces CYP1A2 shifts the balance between Clozapine oral suspension and Norclozapine.