Precursor to metabolite: Tramadol ER to O-desmethyltramadol
Tramadol ER is converted to O-desmethyltramadol by CYP2D6.
The pair
- Tramadol ER — Extended-release tramadol for continuous chronic pain; opioid, serotonergic, and noradrenergic liabilities.
- O-desmethyltramadol — Active tramadol metabolite; much stronger mu agonist than the parent.
Anything that inhibits or induces CYP2D6 shifts the balance between Tramadol ER and O-desmethyltramadol.
Tramadol ER · O-desmethyltramadol · Open Tramadol ER in the interactive console ↗