Precursor to metabolite: Tramadol ER to O-desmethyl- tramadol
Tramadol ER is converted to O-desmethyl- tramadol by CYP2D6.
The pair
- Tramadol ER — Extended-release tramadol for continuous chronic pain; opioid, serotonergic, and noradrenergic liabilities.
- O-desmethyl- tramadol — The active metabolite of tramadol; a much stronger mu agonist than the parent.
Anything that inhibits or induces CYP2D6 shifts the balance between Tramadol ER and O-desmethyl- tramadol.
Tramadol ER · O-desmethyl- tramadol · Open Tramadol ER in the interactive console ↗