Precursor to metabolite: Trazodone to mCPP
Trazodone is converted to mCPP by CYP3A4.
The pair
- Trazodone — Sedating SARI, mostly off-label at low dose for sleep; rare priapism risk.
- mCPP — Trazodone and nefazodone metabolite; 5-HT2C agonist causing anxiety and dysphoria; accumulates when CYP2D6 is inhibited.
Anything that inhibits or induces CYP3A4 shifts the balance between Trazodone and mCPP.
Trazodone · mCPP · Open Trazodone in the interactive console ↗