Precursor to metabolite: Sulindac to Sulindac sulfide

Sulindac is converted to Sulindac sulfide by gut flora + hepatic reduction.

Sulindac mascot — mnemonic cartoon — Sulindac — mascot

The pair

Sulindac — NSAID prodrug for arthritis; liver and severe skin toxicity stand out.
Sulindac sulfide — Active COX-inhibiting metabolite of sulindac; mediates anti-inflammatory effects without eliminating conventional NSAID risks.

Sulindac · Sulindac sulfide · Open Sulindac in the interactive console ↗