Precursor to metabolite: Sulfasalazine to Mesalamine

Sulfasalazine is converted to Mesalamine by colonic azoreductase.

Sulfasalazine mascot — mnemonic cartoon — Visual mnemonic: Sulfasalazine mascot

Mesalamine mascot — mnemonic cartoon — Visual mnemonic: Mesalamine mascot

The pair

Sulfasalazine — DMARD/anti-inflammatory for rheumatoid arthritis and ulcerative colitis.
Mesalamine — Topically acting 5-ASA for ulcerative colitis; delivery system defines the product.

Sulfasalazine · Mesalamine · Open Sulfasalazine in the interactive console ↗