Precursor to metabolite: Sertraline to Desmethyl sertraline
Sertraline is converted to Desmethyl sertraline by CYP2B6.
The pair
- Sertraline — Broadly indicated SSRI with few CYP interactions; GI effects are prominent early.
- Desmethyl sertraline — Long-lived sertraline metabolite and a far weaker serotonin reuptake inhibitor than the parent.
Anything that inhibits or induces CYP2B6 shifts the balance between Sertraline and Desmethyl sertraline.
Sertraline · Desmethyl sertraline · Open Sertraline in the interactive console ↗