Precursor to metabolite: Oxycodone to Oxymorphone
Oxycodone is converted to Oxymorphone by CYP2D6.
The pair
- Oxycodone — Potent oral full-mu opioid for severe pain; high misuse and overdose liability.
- Oxymorphone — Potent semisynthetic mu-opioid agonist; little CYP dependence but full overdose liability.
Anything that inhibits or induces CYP2D6 shifts the balance between Oxycodone and Oxymorphone.
Oxycodone · Oxymorphone · Open Oxycodone in the interactive console ↗