Precursor to metabolite: Midodrine to Desglymidodrine
Midodrine is converted to Desglymidodrine by systemic hydrolysis.
Midodrine — mascot
The pair
Midodrine — Alpha-1 agonist prodrug for orthostatic hypotension.
Desglymidodrine — Active midodrine metabolite that stimulates peripheral alpha-1 receptors; raises standing blood pressure but can cause supine hypertension.