Precursor to metabolite: Methyldopa to α-methylnorepinephrine
Methyldopa is converted to α-methylnorepinephrine by AADC → dopamine beta-hydroxylase.
The pair
- Methyldopa — Central alpha-2 agonist prodrug; a preferred antihypertensive in pregnancy.
- α-methylnorepinephrine — Active methyldopa metabolite; central alpha-2 agonism reduces sympathetic outflow and blood pressure.
Methyldopa · α-methylnorepinephrine · Open Methyldopa in the interactive console ↗