α-methyl norepinephrine
from methyldopa
What it isAlpha-methylnorepinephrine, the CNS metabolite through which methyldopa works.
Why it mattersMethyldopa is a prodrug: this false transmitter stimulates central alpha-2 receptors and lowers sympathetic outflow — the actual antihypertensive.
What it changesIt explains the drug’s lag to effect and its central side effects (sedation, depression) despite a peripheral-looking parent.
NO BOXED WARNINGS
Classes and tags
Clinical profile
Mechanism of action: α-methyl norepinephrine ballicule
