Precursor to metabolite: Imipramine to Desipramine
Imipramine is converted to Desipramine by CYP2C19.
The pair
- Imipramine — The original TCA; prototype antidepressant, now largely supplanted.
- Desipramine — Imipramine metabolite; the most noradrenergic, least sedating TCA.
Anything that inhibits or induces CYP2C19 shifts the balance between Imipramine and Desipramine.
Imipramine · Desipramine · Open Imipramine in the interactive console ↗