Precursor to metabolite: Ibogaine to Noribogaine

Ibogaine is converted to Noribogaine by CYP2D6.

The pair

Ibogaine — Psychoactive alkaloid studied for addiction; cardiac (QT) risk.
Noribogaine — Long-acting active metabolite of ibogaine.

Anything that inhibits or induces CYP2D6 shifts the balance between Ibogaine and Noribogaine.

Ibogaine · Noribogaine · Open Ibogaine in the interactive console ↗