Precursor to metabolite: Dextromethorphan to Dextrorphan
Dextromethorphan is converted to Dextrorphan by CYP2D6.
The pair
- Dextromethorphan — OTC cough suppressant; NMDA antagonist and sigma-1 agonist, dissociative in overdose.
- Dextrorphan — Active dextromethorphan metabolite; NMDA antagonism drives dissociation and abuse potential.
Anything that inhibits or induces CYP2D6 shifts the balance between Dextromethorphan and Dextrorphan.
Dextromethorphan · Dextrorphan · Open Dextromethorphan in the interactive console ↗