Precursor to metabolite: Cyclophosphamide to Phosphoramide mustard
Cyclophosphamide is converted to Phosphoramide mustard by CYP2B6.
The pair
- Cyclophosphamide — DNA-alkylating chemotherapy and immunosuppressant; hemorrhagic cystitis.
- Phosphoramide mustard — DNA-crosslinking metabolite responsible for much of cyclophosphamide's antitumor activity; also drives marrow and reproductive toxicity.
Anything that inhibits or induces CYP2B6 shifts the balance between Cyclophosphamide and Phosphoramide mustard.
Cyclophosphamide · Phosphoramide mustard · Open Cyclophosphamide in the interactive console ↗