Precursor to metabolite: Cyclophosphamide to Acrolein
Cyclophosphamide is converted to Acrolein by CYP2B6.
The pair
- Cyclophosphamide — DNA-alkylating chemotherapy and immunosuppressant; hemorrhagic cystitis.
- Acrolein — Bladder-toxic metabolite of cyclophosphamide and ifosfamide; mesna helps prevent its hemorrhagic cystitis.
Anything that inhibits or induces CYP2B6 shifts the balance between Cyclophosphamide and Acrolein.
Cyclophosphamide · Acrolein · Open Cyclophosphamide in the interactive console ↗