Acrolein
from cyclophosphamide
What it isA reactive aldehyde metabolite of cyclophosphamide and ifosfamide.
Why it mattersConcentrating in urine, it attacks the bladder wall — the cause of hemorrhagic cystitis and the bladder-cancer signal of the oxazaphosphorines.
What it changesMesna exists solely to neutralize it in the urine, which is why mesna co-administration and hydration are standard with these agents.
NO BOXED WARNINGS
Classes and tags
Clinical profile
Mechanism of action: Acrolein ballicule
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Memory aids: mascots and interaction avatars
direct injury to bladder urothelium
the other metabolite of cyclophosphamide is phosphoramide mustard