Xanthine oxidase inhibitor
- ↓ uric-acid production
- Urate-lowering prophylaxis in gout
- Also blocks thiopurine breakdown — reduce thiopurine doses or risk severe toxicity
Drugs with this mechanism (2)
- Allopurinol — Xanthine oxidase inhibitor; first-line urate-lowering for gout prevention.
- Febuxostat — Non-purine xanthine oxidase inhibitor for gout; cardiovascular caution.
Self-check
- What is the gout role of xanthine-oxidase inhibition?
Urate-lowering prophylaxis. - Why must thiopurine doses be reduced with xanthine-oxidase inhibitors?
Thiopurine breakdown is blocked, risking severe toxicity.
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