RdRp inhibitor
Viral RNA-dependent RNA polymerase inhibitor
- Halts replication of RNA viruses
- Some agents chain-terminate; others drive lethal viral mutagenesis
Drugs with this mechanism (3)
- Molnupiravir — Oral COVID antiviral that induces lethal viral mutagenesis.
- Remdesivir — IV antiviral (RdRp inhibitor); the first drug approved for COVID-19.
- Ribavirin — Guanosine analogue antiviral; now an add-on to direct-acting antivirals for hard-to-treat hepatitis C.
Self-check
- Besides chain termination, how can these agents stop RNA viruses?
Lethal viral mutagenesis. - Name a listed viral RNA-polymerase inhibitor.
Remdesivir.
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