Pyrophosphate-site inhibitor
Viral DNA polymerase inhibitor — pyrophosphate site
- A pyrophosphate analogue that blocks the pyrophosphate-binding site directly — no viral or host kinase activation
- Works against acyclovir- and ganciclovir-resistant HSV/CMV because it needs no thymidine kinase or UL97
- Nephrotoxicity and electrolyte wasting (Ca, Mg, K, phosphate) → seizures
- A pyrophosphate analogue that blocks the pyrophosphate-binding site directly — no viral or host kinase activation
- Works against acyclovir- and ganciclovir-resistant HSV/CMV because it needs no thymidine kinase or UL97
- Nephrotoxicity and electrolyte wasting (Ca, Mg, K, phosphate) → seizures
Drugs with this mechanism (1)
- Foscarnet — Needs no viral kinase, so it works against resistant CMV and HSV.
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