TRPV1 agonist

Transient receptor potential vanilloid 1 agonist

Initial activation → desensitization → ↓ pain signaling
➔ same receptor target as capsaicin
May contribute to antiepileptic effect

Drugs with this mechanism (3)

Acetaminophen — OTC analgesic/antipyretic; hepatotoxic in overdose, minimal anti-inflammatory effect.
Cannabidiol — Purified, nonintoxicating cannabinoid for severe developmental epilepsies.
Capsaicin — TRPV1 agonist; topical for neuropathic pain via defunctionalization.

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