TPP cofactor: transketolase
- Connects the pentose phosphate pathway to glycolysis
- Transketolase moves 2-carbon units
- Erythrocyte transketolase activity is the classic thiamine-status assay
Drugs with this mechanism (1)
- Thiamine pyrophosphate — Active thiamine coenzyme required for carbohydrate metabolism; deficiency impairs energy production and contributes to Wernicke encephalopathy.
Self-check
- How many carbons does transketolase transfer at a time?
Two. - Which cell’s transketolase activity is a classic thiamine-status assay?
Erythrocytes.
All mechanisms · Open TPP cofactor: transketolase in the interactive console ↗