TPP cofactor: alpha-ketoglutarate dehydrogenase
- A rate step within the TCA (tricarboxylic acid) cycle
- Same decarboxylation chemistry, applied inside the TCA cycle at alpha-KG → succinyl-CoA
- Impaired in thiamine (B1) deficiency
Drugs with this mechanism (1)
- Thiamine pyrophosphate — Active thiamine coenzyme required for carbohydrate metabolism; deficiency impairs energy production and contributes to Wernicke encephalopathy.
Self-check
- What product forms from alpha-ketoglutarate in this TPP-dependent step?
Succinyl-CoA. - Which vitamin deficiency impairs this reaction?
Thiamine (B1) deficiency.
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