TPO receptor agonist
Thrombopoietin (TPO / MPL) receptor agonist
- Stimulates megakaryocyte platelet production → ↑ platelets in immune thrombocytopenia and aplastic anemia
- Stimulates the MPL receptor on megakaryocytes
- Raises platelet counts in liver-disease thrombocytopenia
- Platelet overshoot → thrombosis
Drugs with this mechanism (2)
- Avatrombopag — Oral TPO-receptor agonist for thrombocytopenia in chronic liver disease or chronic ITP.
- Eltrombopag — Oral thrombopoietin-receptor agonist; cation chelation complicates dosing, while liver injury and thrombosis matter.
Self-check
- Which cells increase platelet production under TPO-receptor stimulation?
Megakaryocytes. - What risk follows platelet overshoot?
Thrombosis.
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