Squalene epoxidase inhibitor
- ↓ ergosterol
- Toxic squalene buildup
- Fungicidal
- Hepatotoxicity; taste disturbance
Drugs with this mechanism (1)
- Terbinafine — Oral antifungal of choice for nail infections; a CYP2D6 inhibitor.
Self-check
- What accumulates toxically when squalene epoxidase is inhibited?
Squalene. - Which sensory disturbance can accompany this antifungal mechanism?
Taste disturbance.
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